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Financial Highlights

Consolidated Key Figures

(thousands of €, if not stated otherwise)

Six months ended June 30, 2025

Six months ended June 30, 2024

Year ended December 31, 2024

Income statement

 

 

 

Supply revenues

18,486

19,105

34,863

Collaboration revenues

121,779

121,200

240,786

Total net revenues

140,265

140,305

275,649

Cost of sales

(18,435)

(19,105)

(34,863)

R&D expenses

(278,027)

(145,225)

(335,459)

S&M, G&A expenses

(74,470)

(63,925)

(134,438)

Other operating income

14,932

16,638

40,773

Operating loss

(215,735)

(71,312)

(188,338)

Net financial results

(45,056)

98,337

185,253

Taxes

1,788

1,139

1,803

Net profit/loss (–) from continuing operations

(259,003)

28,164

(1,282)

Net profit/loss (–) from discontinued operations, net of tax

(148)

71,041

75,364

Net profit/loss (–)

(259,151)

99,205

74,082

 

 

 

 

Income statement from discontinued operations

 

 

 

Product net sales

11,264

11,475

Collaboration revenues

26,041

26,041

Total net revenues

37,305

37,516

Cost of sales

(2,012)

(1,693)

R&D expenses

(12,516)

(11,279)

(8,152)

S&M, G&A expenses

(620)

(10,320)

(12,607)

Other operating income

11,599

54,601

56,180

Operating profit/loss (–)

(1,537)

68,295

71,244

Net financial results

1,921

2,844

4,218

Taxes

(532)

(98)

(98)

Net profit/loss (–) from discontinued operations, net of tax

(148)

71,041

75,364

 

 

 

 

Balance sheet

 

 

 

Cash and cash equivalents

71,669

72,328

64,239

Financial investments

3,019,835

3,358,092

3,253,516

R&D incentives receivables

147,672

172,139

172,611

Assets

3,818,224

4,290,367

4,135,719

Shareholders' equity

2,643,819

2,910,295

2,896,939

Deferred income

954,066

1,186,822

1,071,352

Other liabilities

220,339

193,250

167,428

 

 

 

 

Cash flow

 

 

 

Operational cash burn

(91,529)

(250,041)

(373,961)

Cash flow used in operating activities

(147,388)

(188,867)

(320,026)

Cash flow generated from investing activities

159,452

95,678

220,597

Cash flow used in financing activities

(1,611)

(2,232)

(4,924)

Increase/decrease (–) in cash and cash equivalents

10,453

(95,421)

(104,353)

Effect of currency exchange rate fluctuation on cash and cash equivalents

(3,023)

939

1,782

Cash and cash equivalents at the end of the period

71,669

72,328

64,239

Financial investments at the end of the period

3,019,835

3,358,092

3,253,516

Total financial investments and cash and cash equivalents at the end of the period

3,091,504

3,430,420

3,317,755

 

 

 

 

Financial ratios

 

 

 

Number of shares issued at the end of the period

65,897,071

65,897,071

65,897,071

Basic and diluted earnings/loss (–) per share

(3.93)

1.51

1.12

Share price at the end of the period (in €)

23.76

23.34

26.52

Total group employees at the end of the period (number)

558

683

704

First-Half 2025 Financial Results

On May 13, 2025, we announced a strategic update regarding the company’s intention to separate into two publicly traded entities. Since the initial announcement on January 8, 2025, we made significant progress in reorganizing our business towards the separation, which was expected by mid-2025, subject to shareholder approval and other customary conditions. However, following regulatory and market developments, our Board of Directors decided to re-evaluate the previously proposed separation. As such, we are exploring all strategic alternatives for the existing businesses, including the cell therapy business, with a focus on maximizing resources available for transformative business development transactions.

  • Total operating loss from continuing operations for the six months ended June 30, 2025, was €215.7 million, compared to an operating loss of €71.3 million for the six months ended June 30, 2024. This operating loss was negatively impacted by the strategic reorganization and intended separation, for a total of €131.6 million. This is reflected in severance costs of €47.5 million, costs for early termination of collaborations of €45.7 million, impairment on fixed assets related to small molecules activities of €12.0 million, deal costs of €16.6 million, €8.0 million accelerated non-cash cost recognition for subscription right plans related to good leavers and €1.8 million other expenses.
  • Total net revenues for the six months ended June 30, 2025, amounted to €140.3 million, compared to €140.3 million for the six months ended June 30, 2024. The revenue recognition related to the exclusive access rights granted to Gilead for our drug discovery platform amounted to €115.1 million for the first six months of both 2025 and 2024. Our deferred income balance at June 30, 2025 includes €1.0 billion allocated to our drug discovery platform that will be recognized linearly over the remaining term of the Option, License and Collaboration Agreement (OLCA) with Gilead. We have recognized royalty income from Gilead for Jyseleca® for €5.6 million in the first six months of 2025 (compared to €6.1 million in the same period last year).
  • Cost of sales for the six months ended June 30, 2025, amounted to €18.4 million, compared to €19.1 million in the same period last year, and related to the supply of Jyseleca® to Alfasigma under the transition agreement. The related revenues are reported in total net revenues.
  • R&D expenses in the first six months of 2025 amounted to €278.0 million, compared to €145.2 million for the first six months of 2024. This increase was primarily explained by an increase in subcontracting cost from €64.6 million in the first half-year of 2024 to €141.0 million in the first half-year of 2025 due to increased costs for CAR-T and small molecule programs in oncology, and costs for early termination of collaborations. Personnel costs increased from €42.0 million in the first half of 2024 to €82.3 million for the same period this year due to severance costs. Depreciation and impairment expenses increased from €13.3 million in the first six months of 2024 to €32.2 million in the first six months of 2025 due to impairments on fixed assets related to small molecules activities.
  • S&M expenses amounted to €1.6 million in the first six months of 2025, compared to €7.1 million in the first six months of 2024. The decrease related to the reversal of a bad debt provision on Alfasigma receivables, a decrease in professional fees and other operating expenses.
  • G&A expenses amounted to €72.9 million in the first six months of 2025, compared to €56.8 million in the first six months of 2024. The increase in legal and professional fees, from €15.6 million in the first six months of 2024 to €20.8 million in the first six months of 2025 mainly related to deal costs, while the increase in personnel expenses of €11.7 million (from €25.4 million in the first six months of 2024 to €37.1 million in the same period this year) was due to higher severance costs.
  • Other operating income amounted to €14.9 million in the first six months of 2025, compared to €16.6 million for the same period last year, mainly driven by a reduction of recharges to Alfasigma.

Net financial loss in the first six months of 2025 amounted to €45.0 million (as compared to net financial income of €98.3 million in the same period last year) and consisted mainly of €21.8 million interest income (as compared to €49.4 million interest income in the same period last year) due to the decreased interest rates. Net financial loss in the first six months of 2025 also included €37.9 million of unrealized currency exchange loss on our cash and cash equivalents and current financial investments at amortized cost in U.S. dollar (as compared to €18.2 million unrealized currency exchange gain on cash and cash equivalents and current financial investments in the first six months of 2024), as a result of the fluctuation of the U.S. dollar, and €27.2 million negative changes in fair value of current financial investments (€31.2 million positive changes in the same period last year).

We had €1.8 million of tax income for the first six months of 2025 (as compared to €1.1 million tax income for the same period last year).

Net loss from continuing operations for the first six months of 2025 was €259.0 million, compared to a net profit from continuing operations of €28.2 million for the same period last year.

Net loss from discontinued operations related to Jyseleca® amounted to €0.1 million for the first six months of 2025, compared to a net profit amounting to €71.0 million for the first six months of 2024. The operating profit from discontinued operations for the six months ended June 30, 2024, was mainly related to the gain on the sale of the Jyseleca® business to Alfasigma of €52.3 million.

We reported a net loss for the six months ended June 30, 2025, of €259.1 million, as compared to a net profit of €99.2 million for the six months ended June 30, 2024.

Cash, Cash Equivalents and Financial Investments

Cash and cash equivalents and financial investments totaled €3,091.5 million as of June 30, 2025 (€3,317.8 million as of 31 December 2024).

On June 30, 2025, our cash and cash equivalents and current financial investments included $2,156.2 million held in U.S. dollars ($726.9 million on December 31, 2024) which could generate foreign exchange gains or losses in our financial results in accordance with the fluctuation of the EUR/U.S. dollar exchange rate as our functional currency is EUR.

A net decrease of €226.3 million in cash and cash equivalents and financial investments was recorded during the first six months of 2025, compared to a net decrease of €254.1 million during the first six months of 2024.

This net decrease was composed of (i) €91.5 million of operational cash burn, (ii) €122.7 million of negative exchange rate differences, negative changes in fair value of current financial investments and variation in accrued interest income, (iii) €20.0 million loans and advances given to third parties, partly offset by (iv) €7.9 million of net cash in related to the sale/acquisition of subsidiaries.

The operational cash burn (or operational cash flow if this liquidity measure is positive) is a financial measure that is not calculated in accordance with IFRS. Operational cash burn/cash flow is defined as the increase or decrease in our cash and cash equivalents (excluding the effect of exchange rate differences on cash and cash equivalents), minus:

  1. the net proceeds, if any, from share capital and share premium increases included in the net cash flows generated from/used in (–) financing activities.
  2. the net proceeds or cash used, if any, in acquisitions or disposals of businesses; the acquisition of equity investments held at fair value; the movement in restricted cash and movement in financial investments, if any, the loans and advances given to third parties, if any, included in the net cash flows generated from/used in (–) investing activities.
  3. the cash used for other liabilities related to the acquisition of businesses, if any, included in the net cash flows generated from/used in (–) operating activities.

This alternative liquidity measure is in our view an important metric for a biotech company in the development stage.

The following table provides a reconciliation of the operational cash burn:

Operational cash burn

 

Six months ended June 30

(thousands of €)

2025

2024

Increase/decrease (–) in cash and cash equivalents (excluding effect of exchange differences)

10,453

(95,421)

Less:

 

 

Convertible loan issued to third party

20,000

Net sale of financial investments

(114,041)

(200,307)

Acquisition of equity investments held at fair value

36,880

Cash in/cash out (–) from the disposal of subsidiaries, net of cash disposed of

(9,733)

5,209

Cash used for other liabilities related to the disposal of subsidiaries

3,598

Cash used for other liabilities related to the acquisition of subsidiaries

1,792

Total operational cash burn

(91,529)

(250,041)