Our broad pipeline and powerful drug discovery engine

Our pipeline and drug discovery engine

We discover and develop small molecule medicines with novel modes of action, several of which show promising patient results and are currently in late-stage development in multiple diseases with high unmet medical need. Our highly flexible discovery platform is applicable across many therapeutic areas and our pipeline comprises programs ranging from discovery to Phase 3 and registration phase in inflammation, fibrosis, osteoarthritis, and other indications.

Our clinical pipeline includes: JAK1 inhibitor filgotinib, which is currently filed for approval in RA in the U.S., Europe, and Japan, in Phase 3 trials in UC, CD, and PsA, and in Phase 2 trials in multiple additional indications; autotaxin inhibitor GLPG1690, which is currently in the ISABELA 1 & 2 pivotal trials for idiopathic pulmonary fibrosis (IPF) and the NOVESA Phase 2 proof-of-concept trial in systemic sclerosis (SSc) for which recruitment was completed end of 2019; GLPG1205, a GPR84 inhibitor which completed recruitment in the PINTA Phase 2 proof-of-concept trial in IPF in early 2020; GLPG1972, an ADAMTS-5 inhibitor for which we completed patient recruitment in the ROCCELLA global Phase 2b trial in OA patients in June 2019; and the Toledo molecules GLPG3312, GLPG3970, and GLPG4399, aimed at a novel class of targets we discovered and currently in preclinical and Phase 1 development. Almost exclusively these programs are based on inhibiting targets which were identified using our proprietary target discovery platform.

We have collaborations with Gilead for filgotinib, GLPG1690, and other pipeline assets, with Servier for GLPG1972, with Evotec and Fibrocor for early stage fibrosis programs and with AbbVie in the field of cystic fibrosis (CF). The following table highlights key aspects of our development program indication areas at the beginning of 2020:

Our clinical pipeline

Our clinical pipeline (graphic)