Going concern statement

To date, we have incurred significant operating losses, which are reflected in the balance sheet showing €367.2 million accumulated losses as at 31 December 2021. We realized a consolidated net loss of €103.2 million for the year ended 31 December 2021. Our existing current financial investments and cash and cash equivalents of €4,703.2 million at 31 December 2021 will enable us to fund our operating expenses and capital expenditure requirements at least for the next 12 months. The supervisory board is also of the opinion that additional financing could be obtained, if required. Taking this into account, as well as the potential developments of our drug discovery and development activities, the supervisory board is of the opinion that it can submit the financial statements on a going concern basis. Whilst our current financial investments and cash and cash equivalents are sufficient at least for the next 12 months, the supervisory board points out that if the R&D activities go well, we may seek additional funding to support the continuing development of our products or to be able to execute other business opportunities.